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During host cell infection, CoVs trigger an imbalance involving increased ROS production and reduced antioxidant host responses, thereby leading to increased redox stress, reduced antiviral host responses, and increased virus-induced inflammation and apoptosis, ultimately causing cell and tissue damage and end-organ disease 3

The summary of findings of secondary outcomes and GRADE quality assessment for Comparison 4 is shown in Table 5

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10.1016/j.cbi.2015.08.027 26 KumazawaT.SatoK.SenoH.IshiiA.SuzukiO